Fig. 1

Identification of blood proteins potentially implicated in HF. Manhattan plot depicting blood proteins associated with heart failure (HF) in cis-MR analysis. The localization of the gene encoding the blood protein is represented on the x-axis, whereas the y-axis represents the -log₁₀P value for the association in MR. Red and blue dashed lines are the Bonferroni and FDR 5% threshold values respectively. Red dots are genes positively associated with the development of HF, and green dots are genes negatively associated with the development of HF