Fig. 5

Examples of the substitutions classification for UBCS. The above figure depicts three 300 bp windows of two sequences, Seq 1 (reference) and Seq 2. Within each window substitutions that occurred on Seq 2 with respect to Seq 1 are denoted. The red color of the font is used for weak-to-strong substitutions. In the window A, all substitutions are considered as clustered substitutions (CSs), but not Biased Clustered Substitutions (BCSc), since only 50% of all substitutions are weak-to-strong. In the window B all substitutions are BCSs, because 5 out of 6 (\(\ge\) 80%) substitutions are weak-to-strong. The remaining substitutions from the window C are neither clustered nor biased, because there are four substitution within this window