Fig. 5

Acute exercise-induced changes in signaling pathways. A An enrichment map of core signaling pathways looking for over-representation of component genes in either all significantly (sig.) changing genes or genes that showed a significant and more than 1.5 fold increase in expression. B Signaling pathway genes that showed a significant and more than 1.5 fold change in expression. C GOSt plot (image on left) showing significantly enriched GO terms related to biological processes with adjusted P values [−log10 (p-adj)] on the y axis. The numbers encircled on the GOSt plot represent the GO terms (see table on the right) that are reported by Pillon et al. (PMID: 31980607) to be commonly enriched amongst genes upregulated in response to aerobic exercise in healthy or metabolically impaired subjects (Humans). These GO terms are also over-represented in our acute exercise induced genes