Fig. 1
From: Leveraging family history in genetic association analyses of binary traits
Type I error rate of CC-GWAS, LT-FH and Fam-meta using alpha levels of a 5%, b 1%, and c 0.5% using the following simulation parameters under model 1: The trait heritability was 0.28, and age and sex each explained 10% and 5% of the total variance, respectively. The sample size was 1800, consisting of 400 simple nuclear families. We ran 50,000 simulations under H0, and type I error rate was evaluated as proportion (%) of P-values less than alpha levels of 5%, 1% and 0.5% (indicated by dashed horizontal lines). Exact binomial 95% confidence interval was evaluated for each rate