Fig. 5

The enriched GO BP of DEGs in placental cells at different time points. a The enriched GO BP in JEG-3 cells at 3 h post-ZIKV infection. b The enriched GO BP in JEG-3 cells at 24 h post-ZIKV infection. c-d The enriched GO BP of up-regulated and down-regulated DEGs at 24 h.p.i.. The DEGs at 12 h.p.i. failed to enrich at any GO BP, thus not shown. The enriched GO-BP of up-regulated DEGs at 3 h post-ZIKV infection was shown in Supplementary Table 20, while down-regulated DEGs at 3 h.p.i. failed to enrich at any GO BP, thus not shown. Enrichment analyses were performed by clusterProfiler package of R software. Hypergeometric tests were used to screen enriched GO BPs, and P-values were further adjusted by the default “Holm” method. Those GO BPs with an adjusted P-value < 0.05 were considered significant. Here, the top 20 significant GO BPs ranked by adjusted p-value were displayed