Table 1 Enriched functional clusters based on MCODE analysis of significant proteins related to age, hydration status, and interaction effect
Functional cluster | Â | Enriched GO BP term* | Protein members (symbols) |
|---|---|---|---|
1 | Age-related | extracellular matrix organization | COL4A2; AIFM2; RAE1; OLA1; COL14A1; TMX3; SLC25A20; DNAJC10; GSTO1; ACACB; EIF4A2; COL4A1; GPX1; IPO5; FBLN5; ENO2; ASPN; SARS1; COL18A1 |
2 | muscle contraction | TPM2; TNNI2; MYL3; MTOR; MYH6; TNS1; MYL2; ILK; DMD; TCAP; DES; NEK9; TNNI1; MYH7; MYL6B | |
3 | cell population proliferation | EIF4B; TXNRD1; ALDH2; XPNPEP1; KYAT3; PGRMC1; H3C6; DDB1; PEPD; CMPK1; MFN1; USP9X; CKB; H3-3B; SQSTM1 | |
4 | cellular oxidant detoxification | GSR; MYH10; HSPA2; TXNRD2; MYL4; HADHB; PPIA; RPS27A; TXN; GPX3 | |
5 | carboxylic acid catabolism | PEBP1; ECHDC2; HADHA; ACADSB | |
1 | Hydration status-related | proteasome-mediated ubiquitin-dependent protein catabolic process | PSMD6; YWHAB; DDX6; CCT4; PSMD11; HNRNPD; DNAJA2; PFKL; ILK; IPO5; PSMD1; SOD1; PSMC2; TRIP12; PSMC5; CCT8; CCT5; PSMC4; PSMA4; TCP1; PSMD2; HSP90AB1; HSP90AA1; PSMC1; HUWE1 |
2 | endocytosis | LSM2; ME2; DCTN2; UGP2; GOT2; RPL10A; NME1; GNB1; GRB2; USP15; ACTB | |
3 | amide biosynthetic process | EIF4B; EIF4G1; ACSL4; NAA15; SLIRP; NXF1; RCC1; RPL35; ANK3; EIF2S1; GYS1 | |
4 | actomyosin structure organization | PDGFRB; TPM1; COL4A2; FBLN5; LAMA2; ASPN; LDB3; PDLIM1 | |
5 | extracellular matrix organization | MFAP4; MYL2; MYH2; FBN1; CALU; LAMC1; SVIL; COL18A1; NUP98; LMNA; DMD | |
1 | Interaction-related | muscle contraction | MYL3; FBLN5; NID2; COL18A1; NOS1; TNNI1; MYL2; LAMC1; MYL6B; DMD; LTBP1; MFAP4 |
2 | translation | SNRNP70; RPS15; RPS14; EIF4A2; EIF2A; EIF4B |