Maternal dietary methionine restriction alters hepatic expression of one-carbon metabolism and epigenetic mechanism genes in the ducklings

Sécula, Aurélie; Bluy, Lisa E.; Chapuis, Hervé; Bonnet, Agnès; Collin, Anne; Gress, Laure; Cornuez, Alexis; Martin, Xavier; Bodin, Loys; Bonnefont, Cécile M. D.; Morisson, Mireille

doi:10.1186/s12864-022-09066-7

Table 1 Differentially expressed genes in the liver of ducklings

From: Maternal dietary methionine restriction alters hepatic expression of one-carbon metabolism and epigenetic mechanism genes in the ducklings

Gene	R group LsMeans ± SD (n = 18)	C group LsMeans ± SD (n = 17)	Males LsMeans ± SD (n = 19)	Females LsMeans ± SD (n = 16)	Diet P-value (BH)	Sex P-value (BH)	Sex*Diet P-value (BH)
ATIC	− 0.57 ± 0.21	0.51 ± 0.22	0.22 ± 0.20	− 0.27 ± 0.23	< 0.01	0.54	0.95
HDAC9	−0.71 ± 0.26	0.66 ± 0.27	0.13 ± 0.25	−0.18 ± 0.26	< 0.01	0.77	0.52
EZH2	−0.49 ± 0.20	0.53 ± 0.21	0.00 ± 0.19	0.05 ± 0.21	< 0.01	0.94	0.58
SHMT1	− 0.52 ± 0.21	0.56 ± 0.22	0.10 ± 0.21	−0.06 ± 0.22	< 0.01	0.94	0.95
HSBP1	−0.52 ± 0.20	0.50 ± 0.21	0.23 ± 0.20	−0.25 ± 0.21	0.01	0.51	0.95
GART	−0.56 ± 0.25	0.53 ± 0.29	0.10 ± 0.25	−0.13 ± 0.26	0.01	0.93	0.98
AHCYL1	−0.47 ± 0.22	0.48 ± 0.22	0.10 ± 0.21	−0.08 ± 0.23	0.01	0.94	0.97
CBS	−0.53 ± 0.22	0.51 ± 0.24	−0.05 ± 0.22	0.03 ± 0.23	0.01	0.94	0.52
MSRA	−0.44 ± 0.21	0.50 ± 0.21	−0.02 ± 0.20	0.08 ± 0.23	0.01	0.94	0.52
DNMT3A	−0.43 ± 0.22	0.55 ± 0.25	0.26 ± 0.24	−0.14 ± 0.23	0.02	0.77	0.95
CTH	−0.48 ± 0.24	0.46 ± 0.22	0.10 ± 0.22	−0.13 ± 0.24	0.02	0.94	0.87
FTCD	−0.55 ± 0.30	0.52 ± 0.35	0.03 ± 0.29	−0.06 ± 0.30	0.02	0.94	0.95
*GLRX*	0.27 ± 0.18	−0.37 ± 0.18	0.52 ± 0.17	−0.63 ± 0.19	0.07	< 0.01	0.52
ADK	−0.42 ± 0.25	0.37 ± 0.28	0.27 ± 0.25	−0.32 ± 0.26	0.07	0.31	0.95
MTR	0.33 ± 0.22	−0.40 ± 0.22	0.25 ± 0.21	−0.31 ± 0.23	0.07	0.31	0.95
AHCY	−0.40 ± 0.25	0.41 ± 0.29	0.20 ± 0.26	−0.19 ± 0.26	0.07	0.77	0.95
PLAGL1	−0.37 ± 0.23	0.37 ± 0.23	0.14 ± 0.22	−0.14 ± 0.24	0.07	0.93	0.95
ESR1	−0.32 ± 0.22	0.37 ± 0.23	−0.05 ± 0.21	0.09 ± 0.23	0.07	0.94	0.59
MTHFR	−0.58 ± 0.34	0.43 ± 0.38	−0.01 ± 0.32	−0.15 ± 0.34	0.07	0.94	0.95
PRDM2	−0.37 ± 0.24	0.37 ± 0.24	0.00 ± 0.22	0.00 ± 0.25	0.07	0.95	0.85
WNT11	−0.32 ± 0.23	0.39 ± 0.26	−0.01 ± 0.23	0.08 ± 0.26	0.08	0.94	0.81
EEF1A1	−0.40 ± 0.30	0.46 ± 0.34	0.00 ± 0.29	0.06 ± 0.31	0.09	0.94	0.95
*BHMT*	0.06 ± 0.23	− 0.18 ± 0.25	0.56 ± 0.22	−0.67 ± 0.24	0.70	< 0.01	0.52
*BHMT2*	0.04 ± 0.26	−0.10 ± 0.29	0.51 ± 0.25	−0.57 ± 0.26	0.90	< 0.01	0.55
*DHFR*	−0.08 ± 0.17	−0.08 ± 0.18	0.70 ± 0.16	− 0.86 ± 0.17	0.97	< 0.01	0.78
*MAT2*	−0.31 ± 0.23	0.19 ± 0.25	0.37 ± 0.22	−0.49 ± 0.24	0.30	0.04	0.52
*RBBP4* ^δ	0.17 ± 0.20	− 0.27 ± 0.20	0.33 ± 0.19	−0.43 ± 0.21	0.18	0.06 ^δ	0.52
*HNF4A* ^δ	−0.12 ± 0.22	0.00 ± 0.23	0.36 ± 0.22	−0.47 ± 0.24	0.90	0.08 ^δ	0.58

Numbers, LS-Means, and standard deviations of the gene expression as well as the significance of the effects are given. For the diet effect, the 12 genes differently expressed between the two diet groups (Diet p-value (BH) < 0.05) are listed in the first part of the table whereas the 10 ones which tend to be differently expressed (Diet p-value (BH) < 0.10) are listed in the second part of the table. In addition, for the duckling sex effect, the 5 genes showing a significant effect (Sex P-value (BH) < 0.05) are in bold and the 2 genes which tended to be differentially expressed (Sex P-value (BH) < 0.1) are in bold noted with a delta (^δ). No gene showed a significant interaction between the maternal diet effect and the duckling sex effect (Sex*Diet P-value (BH)). The data used were the qqnorm transformed normalized relative expressions

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