Table 2 Structure and sequence variation of species that present variations in functional domains of NSD1

Domain

Function

Structure

Sequence

PWWP

Present in DNA binding proteins, and involve on protein-protein interactions

deletion: O. garnetti, C. syrichta

deletion: O. garnetti, C. syrichta

NLS1

Translocation signal sequence involve in protein localization inside nucleous

CONSERVED

SNPs: M. musculus, C. syrichta, SNPs: S. apella, O.garnettii

NLS2

CONSERVED

SNPs: M. murinus

NLS3

CONSERVED

SNPs: C. syrichta, M. musculus, SNPs: O.garnettii

PHD1

C4HC3 zinc-finger-like motif found in nuclear proteins involved in epigenetics and chromatin regulation

CONSERVED

SNPs: muscullus, S. apella

PHD2

CONSERVED

SNPs: M. murinus, M. muscullus, P. thephrosceles

RING

E3 ubiquitin-protein ligase activity, binding activity towards E2 ubiquitin-conjugating enzymes

CONSERVED

SNPs: M. muscullus, M. murinus, O.garnettii, P. thephrosceles

PHD3

C4HC3 zinc-finger-like motif found in nuclear proteins involved in epigenetics and chromatin regulation

CONSERVED

SNPs: C. syrichta, M. murinus, O.garnettii

PHD4

CONSERVED

CONSERVED

PWWP2

Present in DNA binding proteins, and involve on protein-protein interactions

CONSERVED

CONSERVED

AWS

Associated With SET, suggesting a role in gene regulation by methylation of lysine residues in histones and other proteins.

CONSERVED

CONSERVED

SET

Histone methyltransferase, modulate gene activities and/or chromatin structure, necessary for the methylation of lysine-9 in the histone H3 N terminus

CONSERVED

SNPs: P. abelli

INHLOOP

Inhibition loop for maintenance of inactive state.

CONSERVED

CONSERVED

Post-SET

Cysteine-rich regions, play a crucial role when it comes to substrate recognition and enzymatic activity

CONSERVED

SNPs: C. syrichta

PHD5

C4HC3 zinc-finger-like motif found in nuclear proteins involved in epigenetics and chromatin regulation

Present different conformation: M. musculus

Deletion: O. garneti