Table 1 Summary of changes detected in the genomes of BCG Pasteur ATCC 35734 and its isogenic derivative BCGΔBCG1419c compared with BCG Pasteur 1173P2
From: Genome sequences of BCG Pasteur ATCC 35734 and its derivative, the vaccine candidate BCGΔBCG1419c
BCG Pasteur ATCC 35734 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHROM | POSITION | TYPE | REF | ALT | EVIDENCE | FTYPE | STRAND | NT_POS | AA_POS | EFFECT | LOCUS_TAG | BCG 1172P2 GENE | H37Rv GENE | PRODUCT |
NC_008769 | 705623 | complex | GTGG | ATGC | ATGC:125 GTGG:0 | CDS | - | 1176/3912 | 391/1303 | synonymous_variant c.1173_1176delCCACinsGCAT p.393 | BCG_RS03180 | BCG_0623c | PE_PGRS7 | PE family protein |
NC_008769 | 1344671 | mnp | CG | GC | GC:119 CG:0 | |||||||||
NC_008769 | 1661323 | snp | G | C | C:12 G:0 | CDS | - | 1926/2223 | 642/740 | synonymous_variant c.1926C > G p.Gly642Gly | BCG_RS07850 | BCG_1513c | PE_PGRS28 | PE family protein |
NC_008769 | 2002385 | complex | G | CGGC | CGGC:61 G:3 | CDS | - | 666/2690 | 222/895 | disruptive_inframe_insertion&synonymous_variant c.666delCinsGCCG p.Thr222_Val223insPro | BCG_RS09290 | BCG_1799c | PE-PGRS family protein wag22b | PE family protein |
NC_008769 | 2764157 | snp | T | A | A:260 T:0 | CDS | - | 459/3342 | 153/1113 | synonymous_variant c.459A > T p.Thr153Thr | BCG_RS12955 | BCG_2507c | Rv2488c | LuxR family transcriptional regulator |
NC_008769 | 2766103 | complex | G | CGGC | CGGC:103 G:0 | CDS | - | 3930/4972 | 1310/1656 | missense_variant&disruptive_inframe_insertion c.3930delCinsGCCG p.Cys1310delinsTrpPro | BCG_RS12965 | BCG_2509c | PE_PGRS43b | PE family protein |
NC_008769 | 3833488 | ins | G | GGCC | GGCC:141 G:9 | CDS | - | 1298/1419 | 433/472 | disruptive_inframe_insertion c.1298_1299insGGC p.Ala433dup | BCG_RS17970 | BCG_3499c | Rv3433c | Bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase |
NC_008769 | 3854969 | ins | G | GGTC | GGTC:289 G:0 | CDS | + | 783/786 | 261/261 | disruptive_inframe_insertion c.782_783insTCG p.Gly261_Ter262insArg | BCG_RS18060 | BCG_3517 | Cut3 | Cutinase family protein |
NC_008769 | 3907860 | snp | A | G | G:81 A:0 | CDS | + | 1795/4119 | 599/1372 | missense_variant c.1795A > G p.Asn599Asp | BCG_RS18320 | BCG_3571 | PE_PGRS53 | PE family protein |
NC_008769 | 3908180 | snp | C | T | T:70 C:0 | CDS | + | 2115/4119 | 705/1372 | synonymous_variant c.2115C > T p.Gly705Gly | BCG_RS18320 | BCG_3571 | PE_PGRS53 | PE family protein |
NC_008769 | 3927720 | snp | A | G | G:13 A:0 | CDS | + | 1792/3228 | 598/1075 | missense_variant c.1792A > G p.Thr598Ala | BCG_RS18350 | BCG_3577 | PE_PGRS57 | PE family protein |
BCGΔBCG1419c | ||||||||||||||
CHROM | POSITION | TYPE | REF | ALT | EVIDENCE | FTYPE | STRAND | NT_POS | AA_POS | EFFECT | LOCUS_TAG | BCG 1172P2 GENE | H37Rv GENE | PRODUCT |
NC_008769 | 705623 | complex | GTGG | ATGC | ATGC:137 GTGG:0 | CDS | - | 1176/3912 | 391/1303 | synonymous_variant c.1173_1176delCCACinsGCAT p.393 | BCG_RS03180 | BCG_0623c | PE_PGRS7 | PE family protein |
NC_008769 | 1344671 | mnp | CG | GC | GC:91 CG:0 | |||||||||
NC_008769 | 1661323 | snp | G | C | C:16 G:0 | CDS | - | 1926/2223 | 642/740 | synonymous_variant c.1926C > G p.Gly642Gly | BCG_RS07850 | BCG_1513c | PE_PGRS28 | PE family protein |
NC_008769 | 2002385 | complex | G | CGGC | CGGC:61 G:0 | CDS | - | 666/2690 | 222/895 | disruptive_inframe_insertion&synonymous_variant c.666delCinsGCCG p.Thr222_Val223insPro | BCG_RS09290 | BCG_1799c | PE-PGRS family protein wag22b | PE family protein |
NC_008769 | 2764157 | snp | T | A | A:266 T:0 | CDS | - | 459/3342 | 153/1113 | synonymous_variant c.459A > T p.Thr153Thr | BCG_RS12955 | BCG_2507c | Rv2488c | LuxR family transcriptional regulator |
NC_008769 | 2766103 | complex | G | CGGC | CGGC:110 G:0 | CDS | - | 3930/4972 | 1310/1656 | missense_variant&disruptive_inframe_insertion c.3930delCinsGCCG p.Cys1310delinsTrpPro | BCG_RS12965 | BCG_2509c | PE_PGRS43b | PE family protein |
NC_008769 | 2828791 | snp | G | A | A:155 G:0 | |||||||||
NC_008769 | 3833488 | ins | G | GGCC | GGCC:159 G:6 | CDS | - | 1298/1419 | 433/472 | disruptive_inframe_insertion c.1298_1299insGGC p.Ala433dup | BCG_RS17970 | BCG_3499c | Rv3433c | Bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase |
NC_008769 | 3854969 | ins | G | GGTC | GGTC:279 G:0 | CDS | + | 783/786 | 261/261 | disruptive_inframe_insertion c.782_783insTCG p.Gly261_Ter262insArg | BCG_RS18060 | BCG_3517 | Cut3 | Cutinase family protein |
NC_008769 | 3907860 | snp | A | G | G:37 A:0 | CDS | + | 1795/4119 | 599/1372 | missense_variant c.1795A > G p.Asn599Asp | BCG_RS18320 | BCG_3571 | PE_PGRS53 | PE family protein |
NC_008769 | 3908180 | snp | C | T | T:99 C:1 | CDS | + | 2115/4119 | 705/1372 | synonymous_variant c.2115C > T p.Gly705Gly | BCG_RS18320 | BCG_3571 | PE_PGRS53 | PE family protein |
NC_008769 | 3927720 | snp | A | G | G:11 A:0 | CDS | + | 1792/3228 | 598/1075 | missense_variant c.1792A > G p.Thr598Ala | BCG_RS18350 | BCG_3577 | PE_PGRS57 | PE family protein |