Fig. 6

GO functional classification and KEGG pathway annotation classification of target genes. a GO functional classification of negatively correlated target genes; b GO functional classification of positively correlated target genes; c Negatively correlated target gene pathway annotation; d Positively correlated target gene pathway annotation. The size and color of the bubble represent the number of enriched genes and enrichment significance, respectively. KEGG analysis was performed based on the method as described by Kanehisa et al. [34]