Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome

Table 1 Genes associated with XFS and replicated in European Ancestry individuals

*Chromosome*	*Genes associated with XFS*
chr1	^aLGR6;^aSDHB
chr6	^aPRRT1
chr8	^aPRSS55
chr10	PITRM1;*^aCDH23
chr11	^aTMEM136
chr15	SEMA7A*;STOML1;ADPGK;MPI;HEXA;LOXL1*;CPLX3;INSYN1*; SCAMP5;ISLR;CYP11A1;*NPTN;CSK*;NEO1;UBL7*;CD276;STRA6; PARP6;LMAN1L*;ISLR2;ARID3B;CLK3;PML;SCAMP2;^aTBC1D21; CYP1A2;CYP1A1;^aRPP25;^bULK3**
chr16	^bCDYL2**
chr19	^aCALM3

Gene associated with XFS in single tissues analysis at genome-wide significance threshold (< 2.02e-7) in global GWAS summary statistic
Gene associated with XFS in cross-tissue analysis (< 9.5e-6) and in single tissues analysis at suggestive significance threshold (<1e-4) in global GWAS summary statistics
Significance values in European ancestry data single tissue analysis of genes associated with XFS ***p value< 2..02e7, ** p value <1e-4, * p value < 0.05
^agenes associated with XFS in global dataset but with no association signals in European ancestry data at even nominal threshold (< 0.05)
^bAdditional genes associated with XFS in cross-tissue analysis of European ancestry data but not in global dataset

ISSN: 1471-2164