Genome-wide identification of RNA modification-related single nucleotide polymorphisms associated with rheumatoid arthritis

Table 2 Associations between gene expressions in blood cells and RA identified in SMR and HEIDI analysis

Targeted RNAm-SNPs	CHR	Position^a	Allele1	Allele2	GWAS			eQTL					SMR			HEIDI
Targeted RNAm-SNPs	CHR	Position^a	Allele1	Allele2	Beta	SE	P value	Beta	SE	P value	Gene	Study	Beta	SE	P value	P value
rs9277410	6	33,051,640	A	G	−0.2877	0.0134	1.50E-85	0.7568	0.0567	1.25E-40	HLA-DPB2	GTEx	−0.3801	0.0336	9.53E-30	2.67E-01
rs4836834	9	123,665,901	T	A	0.0726	0.0109	3.90E-09	−0.1219	0.0195	3.83E-10	PHF19	Westra	− 0.5951	0.1302	4.89E-06	8.50E-02
rs4836834	9	123,665,901	T	A	0.0726	0.0109	3.90E-09	−0.3401	0.0190	8.97E-72	TRAF1	Westra	−0.2134	0.0341	3.77E-10	9.14E-01
rs4836834	9	123,665,901	T	A	0.0726	0.0109	3.90E-09	−0.3580	0.0275	1.16E-38	TRAF1	CAGE	−0.2027	0.0341	2.76E-09	9.76E-02
rs2952151	17	37,828,496	T	C	−0.0834	0.0164	5.70E-09	0.4255	0.0301	2.04E-45	PGAP3	CAGE	−0.1960	0.0409	1.65E-06	9.65E-02
rs9303280	17	38,074,031	C	T	−0.0770	0.0140	1.70E-09	0.2928	0.0269	1.29E-27	GSDMB	GTEx	−0.2629	0.0535	8.96E-07	1.56E-01
rs9303280	17	38,074,031	T	C	0.0770	0.0140	1.70E-09	−0.3388	0.0276	1.46E-34	GSDMB	CAGE	−0.2272	0.0452	5.10E-07	2.55E-01

CHR Chromosome; GWAS Genome-wide association study; HEIDI: heterogeneity in dependent instruments; SE Standard error, SMR summary data–based Mendelian randomization
^aGenomic Assembly: GRCh37.p13

ISSN: 1471-2164