Fig. 5

REACTOME analysis of mRNA changes up to 1 week. Using PANTHER gene expression analysis tool, selecting for Macaca mulatta organism, using the statistical overrepresentation test (Reactome pathways) and Macaca mulatta reference whole genome, then selecting Fisher’s exact test and Bonferroni correction for multiple testing, the REACTOME categories that passed the corrected Bonferroni p-value cut off of 0.05 are shown below. Next, we merged the list and used VLOOKUP in Microsoft excel to sort the Bonferroni p-values in ascending order at the 3 time points as shown. The color scale indicated the range of Bonferroni p-values from deep green (10^–36) to yellow (10^–2) for these pathways. Overlapping processes such as eukaryotic translation, influenza life cycle and infection, rRNA processing were affected at all time points up to 1 week at the mRNA level. Processes related to Oncogene induced senescence and SMAD regulation of transcriptional activity appeared only at day 5 to 7