Fig. 5

Protein-protein interaction network analysis of down-regulated proteins. a, PE-Un-FE vs. PE-0 min-FE; b, AE-Un-FE vs. AE-0 min-FE; c, PE-0 min-FE vs. PE-30 min-FE; d, AE-0 min-FE vs. AE-30 min-FE. Dashed lines encompass clusters of interacting proteins involved in physiological processes. Network nodes (spheres) represent all the proteins produced by a single, protein-coding gene locus, excluding splice isoforms or post-translational modifications. Each node is named for the zebrafish proteins to which spectra were mapped (see Additional file 1 for full protein names). Edges (colored lines) represent protein-protein associations which are meant to be specific and meaningful. Model statistics are presented at the bottom of each figure