Fig. 2

Splicing entropy of events from different types of genes. The bean charts display differential splicing entropy of AS events in genes with different categories. A Housekeeping genes (n = 16,387) vs. Non-housekeeping genes (n = 35,205). B gene age, Young: human-specific genes (n = 315), Old: non-human-specific genes (n = 40,342). C expression level, Low: TPM < 50 (n = 39,838), High: TPM ≥ 50 (n = 11,754). D gene expression tissue specificity, Low tissue specificity: tau < 0.3 (event number: 24,229), High tissue specificity: tau ≥ 0.3 (n = 27,363). E Evolutionary rate, Low (slow-evolving): 0.000923 ≤ dN/dS ≤ 0.0993 (n = 45,272), High (fast-evolving): 0.0993 < dN/dS ≤ 29.3 (n = 45,256). F degree in protein–protein interaction (PPI) network, Low degree: 2 ≤ degree ≤ 1.34 × 10³ (n = 25,442); High degree: 1.34 × 10³ ≤ degree ≤ 1.38 × 10⁴ (n = 25,350). All significances were evaluated with Wilcoxon rank-sum test. Dashed lines indicate the median of all two groups of CE events, solid vertical lines indicate median for each group of events