Fig. 10

Partial sequence alignment of L. luymesi ATHs and human PGGHG. HsPGGHG, Homo sapiens PGGHG (NCBI accession no. NP_079368.3); LlATH1/2, L. luymesi acid trehalase 1/2. Identical amino acids are marked by an asterisk and shaded in grey. More than 50% of the conserved residues are shaded in blue. The amino acids in red indicate that three carboxyl residues (corresponding to Asp301, Glu430 and Glu574 of human PGGHG) are essential for catalytic activity