Fig. 5

A Overview of cholesterol synthesis pathway in L. luymesi. Circles represent the following enzymes: 1, acetyl-CoA acetyltransferase; 2, hydroxymethylglutaryl-CoA synthase; 3,3-hydroxy-3-methylglutaryl-coenzyme A reductase; 4, mevalonate kinase; 5, promyelvalonate kinase; 6, diphosphomevalonate decarboxylase; 7, isopentenyl-diphosphate delta-isomerase; 8, farnesyl pyrophosphate synthase; 9, geranylgeranyl pyrophosphate synthase; 10, squalene synthase; 11, squalene monooxygenase; 12, lanosterol synthase; 13, lanosterol 14-alpha demethylase; 14, delta(14)-sterol reductase; 15, lamin-B receptor; 16, sterol-4-alpha-carboxylate 3-dehydrogenase; 17, 3-keto-steroid reductase; 18, lathosterol oxidase; 19, 7-dehydrocholesterol reductase. C. elegans lacks the branch inside the dashed box. B Heatmap of FPKM expression values for the annotated genes in L. luymesi cholesterol synthesis pathway from three individual samples (TW1, TW2 and TW3). FPKM values were listed in Table S4