Fig. 1

(A) Venn diagram demonstrating the common compounds identified by the three different drug repurposing platforms, iLINCS, CLUE and L1000CDS², that could reverse the monocytes signature. To identify the 7 common compounds between the 3 different tools, all compounds derived from each different tool (iLINCS, CLUE and L1000), that could reverse the monocytes signature, were included in the Venn diagram. (B) Venn diagram to determine the top ranked drugs from all the three different drug repurposing platforms, that reverse exclusively our monocytes signature and not the signatures of B-cells, CD4⁺ and CD8⁺-T cells. For this Venn diagram the top-50 ranked compounds derived exclusively from each different tool (iLINCS, CLUE and L1000) that could reverse the monocytes, the B-cells, CD4⁺ and CD8⁺-T cells signature respectively, were included. Concerning the iLINCS tool the top-50 ranked compounds from each of the 5 different libraries were included. Conclusively, via this Venn diagram, 179 compounds were identified to reverse exclusively the monocytes signature