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Fig. 2 | BMC Genomics

Fig. 2

From: Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy

Fig. 2

Interaction network integrating the protein coding differentially expressed genes (DEGs) identified by the differential expression analysis of the monocytes from SLE patients versus healthy individuals, the transcription factors identified to regulate their expression and the miRNAs that are associated with them. The size of each node is scaled according to the degree of its interconnectivity, with highly interconnected nodes depicted larger. Only nodes with degree > 3 were depicted. Genes encoding the interleukins IL-6, IL-1b as well as genes implicated in the JAK/STAT pathway were among the most highly interconnected nodes

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BMC Genomics

ISSN: 1471-2164

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