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Fig. 3 | BMC Genomics

Fig. 3

From: Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy

Fig. 3

Interaction network combining the protein coding differentially expressed genes (DEGs), the transcription factors and the miRNAs as defined in Fig. 2 and the drugs that are predicted to interact with the DEGs, according to the DGIdb database. Nodes with degree > 2 were included in the network on the right side of the graph. From the nodes included in the network on the right side of the graph, we selected the DEGs, transcription factors and miRNAs with degree > 10, as depicted in the network on the left side of the graph. Among others, the monoclonal antibodies targeting the IL12/IL23 as well as the TNF pathways were identified

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BMC Genomics

ISSN: 1471-2164

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