Fig. 1

Validating alpha, beta, and delta chromatin accessibility ATAC Seq. A Dimensional reduction through principal component analysis across seven samples from all three cell types (See Table-S1 for details). All three cell type’s replicates clustered closer together and separate from other cell types. B Heatmap further confirming quality of replicates and similarity between replicates within each cell type. C Fraction of Reads in Peaks (FRiP) score evaluation across samples, confirming high library complexity irrespective of depth of sequencing. D-F Confirming chromatin normalized accessibility at the TSS (arrows) against normalized bulk RNA-Seq expression in key islet cell type-specific marker gene regions—Ins2, Gcg, and Sst—in beta, alpha, and delta cells, respectively