Fig. 6

Differentially enriched chromatin at TSS genic regions and their respective gene’s expression between alpha, beta, and delta cells. A-C Schematic of ‘congruent’, ‘incongruent’, and ‘unexpressed’ categories used to determine the association of enriched chromatin at TSS genic regions and respective gene expression. D Differentially enriched chromatin at TSS genic regions and their respective gene’s expression between alpha and beta cells. The majority (50%) of genes with enriched chromatin at promoter-proximal regions around their TSS had correlated gene expression (congruent). Another 36% of chromatin enriched TSS regions showed repressed gene expression for each cell type (alpha repressed (33%) or beta repressed (3%)), and finally, 14% were unexpressed. E Differentially enriched chromatin at TSS genic regions and their respective gene’s expression between alpha and delta cells. The majority (55%) of genes with enriched chromatin had correlated gene expression (congruent). Another 24% of chromatin enriched TSS genic regions showed repressed gene expression for each cell type (alpha repressed (14%) or delta repressed (10%)), and finally, 20% showed no expression. F Differentially enriched chromatin at TSS genic regions and their respective gene’s expression between beta and delta cells. The majority (57%) of genes with enriched chromatin had correlated gene expression (congruent). Another 32% of chromatin enriched TSS regions showed repressed gene expression for each cell type (beta repressed (1.5%) or delta repressed (30.45%)), and finally, 11% showed no difference