Fig. 8

Evaluating expressed, cell-specific transcription factor motifs on differentially enriched peaks across cell types. A Evaluating cell-specific transcription factor motifs associated with differentially enriched peaks for alpha and beta cells, suggesting transcription factor preference for these peaks across the functionally annotated genome. Notably, three known transcription factors were predicted to overlap all defined regions of the genome, whereas others showed preference for binding at either promoter, exon, intron, or distal regions, suggesting different mechanisms of regulation. B Evaluating cell-specific transcription factor motifs associated with differentially enriched peaks for alpha and delta cells, suggesting transcription factor preference for these peaks across the functionally annotated genome. No known transcription factor was predicted to bind to all defined regions of the genome, with the majority binding to either intronic, distal, or promoter areas. C Evaluating cell-specific transcription factor motifs associated with differentially enriched peaks for beta and delta cells, suggesting transcription factor preference for these peaks across the functionally annotated genome. No known transcription factor was found predicted to bind to all defined regions of the genome, with the great majority showing a preference for distal, intronic, or promoter regions