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Table 5 The interaction models based on the GMDR

From: Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study

Model

Cross-validation consistency

Training balanced accuracy

Test balanced accuracy

P

Shift

7/10

0.5543

0.5319

0.172

MTNR1B-Shift

8/10

0.5777

0.5457

0.377

MTNR1B-CLOCK-Shift

5/10

0.5924

0.5171

0.172

MTNR1A-MTNR1B-CLOCK-Shift

10/10

0.6137

0.5574

0.011

  1. Adjusted for age, sex, smoking status, drinking status, physical activity, DASH score, dyslipidaemia, hypertension, liver dysfunction, renal dysfunction and exposure to occupational hazards (high temperature, noise, dust and carbon monoxide (CO))
  2. DASH dietary approaches to stop hypertension, BMI body mass index, RERI Relative excess risk due to interaction, AP Attributable proportion; shift: rotating night shift work
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BMC Genomics

ISSN: 1471-2164

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