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Fig. 2 | BMC Genomics

Fig. 2

From: Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications

Fig. 2

Correlation between H3K4me1 and DNA hypermethylation at promoter CGIs of cancer cells. A Heatmaps showing pairwise spearman correlation coefficients among multiple epigenetic modifications and gene expression. N, normal colon tissue. T, COAD. TPM: transcripts per million. B Up panels show the level and pattern of H3K4me1 (left) and H3K4me3 (right) at promoter CGIs and flanked regions in normal colon tissue and COAD. Lower panels show quantification of the levels of H3K4me1 at promoter CGIs of 5 group genes in normal colon tissue and COAD. Data were presented as mean ± SD. Statistical analysis was performed by Wilcoxon Rank Sum, ns: not significantly, **** p < 0.0001. C Distribution pattern and level of H3K4me1 at promoter CGIs and flanked regions in high-H3K4me1 group and low-H3K4me1 group. D Box plot showing DNA methylation level at promoter CGIs in normal colon tissue and COAD. Data were presented as mean ± SD. Statistical analysis was performed by Wilcoxon Rank Sum, ns: not significantly, **** p < 0.0001

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BMC Genomics

ISSN: 1471-2164

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