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Fig. 4 | BMC Genomics

Fig. 4

From: Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors

Fig. 4

High distal accessibility in HepLPC-P3 and HepLPC-P10 was associated with the conversion of PHCs to HepLPCs. A Heatmap of regions with significantly high accessibility in HepLPC-P3 and HepLPC-P10 (FDR <  = 0.05); the heatmap is centered on the ATAC-seq peak (upstream 3 kb and downstream 3 kb of the peaks). B Bar plot for the enrichment of the regions with significantly high accessibility in HepLPC-P3 and HepLPC-P10 in promoter (< = 3 kb) and distal regions. The enrichment score represents the log2-transformed observed overlapping peaks / the expected overlapping peaks. C KEGG pathway enrichment analysis in genes with high distal accessibility in HepLPC-P3 and HepLPC-P10 indicated that pathways involved in cell growth and proliferation were enriched. D Top 5 high-expressed known TFs enriched in HepLPC-P3/P10 high distal accessibility regions. E Heatmap showing the z-scores of log2-transformed expression values of the TFs in D based on RNA-seq data

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BMC Genomics

ISSN: 1471-2164

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