Table 2 GO and KEGG pathways enriched in the candidate reference genes
| Â | ID code | Term/ Pathway | Subgroup | Gene number | Q value |
|---|---|---|---|---|---|
Early development | GO | Â | Â | Â | Â |
GO:0044267 | cellular protein metabolic process | Biological process | 679 (19.73%) | 0.000000 | |
GO:0044260 | cellular macromolecule metabolic process | Biological process | 1518 (44.1%) | 0.000000 | |
GO:0044237 | cellular metabolic process | Biological process | 1883 (54.71%) | 0.000000 | |
GO:0046907 | intracellular transport | Biological process | 281 (8.16%) | 0.000000 | |
GO:0005622 | intracellular | Cellular component | 1315 (57%) | 0.000000 | |
GO:0005623 | cell | Cellular component | 1414 (61.29%) | 0.000000 | |
GO:0044464 | Cell part | Cellular component | 1414 (61.29%) | 0.000000 | |
GO:0044424 | intracellular part | Cellular component | 1263 (54.75%) | 0.000000 | |
GO:0043226 | organelle | Cellular component | 1032 (44.73%) | 0.000000 | |
GO:0043229 | intracellular organelle | Cellular component | 1014 (43.95%) | 0.000000 | |
GO:0005488 | binding | Molecular function | 3127 (72.4%) | 0.000000 | |
GO:0005515 | protein binding | Molecular function | 1612 (37.32%) | 0.000000 | |
GO:0043168 | anion binding | Molecular function | 753 (17.43%) | 0.000000 | |
GO:0000166 | nucleotide binding | Molecular function | 737 (17.06%) | 0.000000 | |
KEGG | Â | Â | Â | Â | |
ko03010 | Ribosome | Â | 89 (4.38%) | 0.000000 | |
ko03050 | Proteasome | Â | 37 (1.82%) | 0.000000 | |
ko04141 | Protein processing in endoplasmic reticulum | Â | 97 (4.77%) | 0.000000 | |
ko04120 | Ubiquitin mediated proteolysis | Â | 84 (4.13%) | 0.000001 | |
ko03420 | Nucleotide excision repair | Â | 33 (1.62%) | 0.000002 | |
ko05171 | Coronavirus disease—COVID-19 |  | 75 (3.69%) | 0.000010 | |
Normal adult tissues | GO | Â | Â | Â | Â |
GO:0044267 | cellular protein metabolic process | Biological process | 743 (20.74%) | 0.000000 | |
GO:0046907 | intracellular transport | Biological process | 298 (8.32%) | 0.000000 | |
GO:0051649 | establishment of localization in cell | Biological process | 323 (9.01%) | 0.000000 | |
GO:0044260 | cellular macromolecule metabolic process | Biological process | 1577 (44.01%) | 0.000000 | |
GO:0005622 | intracellular | Cellular component | 1364 (57.97%) | 0.000000 | |
GO:0044424 | intracellular part | Cellular component | 1312 (55.76%) | 0.000000 | |
GO:0005623 | cell | Cellular component | 1458 (61.96%) | 0.000000 | |
GO:0044464 | cell part | Cellular component | 1458 (61.96%) | 0.000000 | |
GO:0043226 | organelle | Cellular component | 1084 (46.07%) | 0.000000 | |
GO:0,043,229 | intracellular organelle | Cellular component | 1056 (44.88%) | 0.000000 | |
GO:0005488 | bind | Molecular function | 3371 (74.51%) | 0.000000 | |
GO:0005515 | protein binding | Molecular function | 1763 (38.97%) | 0.000000 | |
GO:0043168 | anion binding | Molecular function | 801 (17.71%) | 0.000000 | |
GO:0017076 | purine nucleotide binding | Molecular function | 668 (14.77%) | 0.000000 | |
KEGG | Â | Â | Â | Â | |
ko03010 | Ribosome | Â | 96 (5.02%) | 0.000000 | |
ko00190 | Oxidative phosphorylation | Â | 67 (3.51%) | 0.000000 | |
ko03050 | Proteasome | Â | 38 (1.99%) | 0.000000 | |
ko05171 | Coronavirus disease—COVID-19 |  | 85 (4.45%) | 0.000000 | |
ko05415 | Diabetic cardiomyopathy | Â | 85 (4.45%) | 0.000000 | |
ko05016 | Huntington disease | Â | 141 (7.38%) | 0.000000 | |
Hindgut under sulfide stress | GO | Â | Â | Â | Â |
GO:0006468 | protein phosphorylation | Biological process | 329 (4.82%) | 0.000000 | |
GO:0007264 | small GTPase mediated signal transduction | Biological process | 225 (3.3%) | 0.000000 | |
GO:0051641 | cellular localization | Biological process | 558 (8.18%) | 0.000000 | |
GO:0051649 | establishment of localization in cell | Biological process | 513 (7.52%) | 0.000000 | |
GO:0005622 | intracellular | Cellular component | 2248 (48.43%) | 0.000000 | |
GO:0005623 | cell | Cellular component | 2461 (53.02%) | 0.000000 | |
GO:0044464 | cell part | Cellular component | 2461 (53.02%) | 0.000000 | |
GO:0044424 | intracellular part | Cellular component | 2147 (46.25%) | 0.000000 | |
GO:0043226 | organelle | Cellular component | 1776 (38.26%) | 0.000000 | |
GO:0043229 | intracellular organelle | Cellular component | 1729 (37.25%) | 0.000000 | |
GO:0005515 | protein binding | Molecular function | 3325 (38.6%) | 0.000000 | |
GO:0005488 | binding | Molecular function | 6141 (71.3%) | 0.000000 | |
GO:0043168 | anion binding | Molecular function | 1372 (15.93%) | 0.000000 | |
GO:0017076 | purine nucleotide binding | Molecular function | 1119 (12.99%) | 0.000000 | |
KEGG | Â | Â | Â | Â | |
ko05415 | Diabetic cardiomyopathy | Â | 102 (3.23%) | 0.000004 | |
ko00190 | Oxidative phosphorylation | Â | 73 (2.31%) | 0.000004 | |
ko05017 | Spinocerebellar ataxia | Â | 97 (3.07%) | 0.000008 | |
ko03050 | Proteasome | Â | 38 (1.2%) | 0.000013 | |
ko04136 | Autophagy—other |  | 36 (1.14%) | 0.000026 | |
ko04120 | Ubiquitin mediated proteolysis | Â | 107 (3.39%) | 0.000026 |