Metabolomic analysis reveals the influence of HMBOX1 on RAW264.7 cells proliferation based on UPLC-MS/MS

BMC Genomics

Table 1 Information of differential metabolites in HMBOX1-overexpressed RAW264.7 in response to LPS.

Compound	Fold change	p-value	m/z	rt(s)	Adduct	Ionisation Mode
L-Serine	0.467	0.001	104.035	318.322	(M-H)⁻	−
L-Threonine	0.474	0.010	118.051	301.351	(M-H)⁻	−
Pyruvate	0.380	0.015	87.009	121.803	(M-H)⁻	−
Guanidoacetic acid	0.407	0.000	118.061	361.471	[M + H]⁺	+
Creatine	0.555	0.002	154.059	356.294	[M + Na]⁺	+
5-aminolevulinic acid	0.711	0.002	114.066	172.044	[M + H-H₂O]⁺	+
Betaine	0.785	0.031	118.086	286.827	[M + H]⁺	+
Ketoleucine	0.284	0.001	129.056	43.912	[M-H]⁻	−
L-Isoleucine	0.356	0.014	130.087	247.704	[M-H]⁻	−
DL-isoleucine	0.447	0.002	132.102	286.146	[M + H]⁺	+
D-aspartic acid	1.749	0.000	132.030	424.707	[M-H]⁻	−
N-acetyl-l-aspartic acid	0.708	0.000	176.041	356.294	[M + H]⁺	+
Glutamine	0.429	0.000	147.076	372.540	[M + H]⁺	+
L-Proline	0.493	0.036	114.056	270.866	[M-H]⁻	−
Agmatine	0.344	0.000	131.118	421.243	[M + H]⁺	+
L-hydroxyarginine	0.545	0.037	116.071	331.547	[M + H-CH₅ON₃]⁺	+
Pantothenate	0.494	0.002	218.103	247.003	[M-H]⁻	−
Beta-alanine	0.665	0.000	90.055	366.517	[M + H]⁺	+
Quinolinate	3.131	0.000	150.022	127.883	[M + H-H₂O]⁺	+
Pantothenic acid	0.620	0.007	220.118	291.144	[M + H]⁺	+
Uridine	0.339	0.000	267.065	288.039	[M + Na]⁺	+
5-methylcytosine	0.200	0.000	126.066	46.761	[M + H]⁺	+
Uridine 5’-diphosphate (UDP)	1.827	0.028	405.009	419.068	[M + H]⁺	+
Phytosphingosine	1.454	0.003	318.300	44.625	[M + H]⁺	+
Pro-Trp	1.302	0.008	302.305	44.102	[M + H]⁺	+

ISSN: 1471-2164