Table 1 Detailed information of nonsynonymous breed-specific SNPs identified across breeds

Airedale Terrier (n = 4)

chr2

IRX6: Iroquois Homeobox 6

148/443

Arginine

Cysteine

chr11

LOC119874041: Uncharacterized gene

843/1321

Valine

Glycine

chr11

859/1321

Proline

Threonine

chr11

888/1321

Leucine

Methionine

chr17

C17H2orf78: Chromosome 17 homolog 2 open reading frame 78

190/933

Proline

Serine

chr18

LOC541568: Uncharacterized gene

276/327

Isoleucine

Methionine

chr18

DUSP8: Dual Specificity Phosphatase 8

8/625

Arginine

Tryptophan

chr19

NCKAP5: NCK Associated Protein 5

1805/1952

Leucine

Glutamine

chr33

GAP43: Growth Associated Protein 43

236/243

Arginine

Histidine

Akita (n = 5)

chr1

LOC119870150: Uncharacterized gene

156/233

Serine

Phenylalanine

chr5

ARHGEF12: Rho Guanine Nucleotide Exchange Factor 12

468/1543

Methionine

Isoleucine

chr11

NFX1: Nuclear Transcription Factor, X-Box Binding 1

667/1118

Leucine

Phenylalanine

chr11

AQP3: Aquaporin 3

13/324

Glutamic acid

Lysine

chr11

NOL6: Nucleolar Protein 6

322/1146

Phenylalanine

Leucine

chr15

LOC106559783: Uncharacterized gene

122/210

Alanine

Valine

chr16

KLKB1: Kallikrein B1

147/690

Threonine

Arginine

chr17

EIPR1: EARP Complex And GARP Complex Interacting Protein 1

44/317

Serine

Glycine

chr20

SLMAP: Sarcolemma Associated Protein

457/865

Serine

Alanine

chr20

NIBAN3: Niban Apoptosis Regulator 3

559/623

Asparagine

Serine

chr20

552/623

Glycine

Arginine

chr20

465/623

Asparagine

Aspartic acid

chr20

JSRP1: Junctional Sarcoplasmic Reticulum Protein 1

80/391

Leucine

Proline

chrX

LOC119863881: Uncharacterized gene

107/174

Aspartic acid

Glycine

chrX

LOC119863881: Uncharacterized gene

113/174

Leucine

Phenylalanine

Alaskan Malamute (n = 4)

chr3

SLC2A9: Solute Carrier Family 2 Member 9

426/435

Glycine

Arginine

chr6

BTBD8: BTB Domain Containing 8

636/1731

Arginine

Lysine

chr13

TMEM71: Transmembrane Protein 71

59/311

Tyrosine

Histidine

chr26

LOC119866109: Uncharacterized gene

100/287

Arginine

Glycine

chr28

PIK3AP1: Phosphoinositide-3-Kinase Adaptor Protein 1

492/821

Asparagine

Serine

chr33

FBXO40: F-Box Protein 40

565/712

Leucine

Phenylalanine

chr33

GOLGB1: Golgin B1

2910/2930

Histidine

Tyrosine

Basset Hound (n = 6)

chr6

ATP5J2:ATP Synthase Membrane Subunit F

686/752

Tyrosine

Cysteine

chr6

MYH16: Myosin Heavy Chain 16

1746/1993

Glutamine

Stop

chr6

KDELR2: Endoplasmic Reticulum Protein Retention Receptor 2

132/207

Arginine

Glycine

Bernese Mountain Dog (n = 5)

chr1

MEGF8: Multiple EGF Like Domains 8

2514/2792

Arginine

Glutamine

chr3

SLC28A1: Solute Carrier Family 28 Member 1

8/629

Arginine

Stop

chr5

TM4SF5: Transmembrane 4 L Six Family Member 5

77/197

Glycine

Serine

chr5

ANGPTL3: Angiopoietin Like 3

228/459

Leucine

Phenylalanine

chr16

FAT1: FAT Atypical Cadherin 1

925/4603

Proline

Arginine

Border Terrier (n = 4)

chr7

LOXHD1: Lipoxygenase Homology PLAT Domains 1

518/2224

Asparagine

Serine

Boxer (n = 4)

chr9

MYADML2: Myeloid Associated Differentiation Marker Like 2

128/307

Arginine

Glycine

chr9

SAP30BP: SAP30 Binding Protein

54/322

Threonine

Asparagine

chr9

MYO15B: Myosin XVB

1577/2964

Histidine

Tyrosine

chr9

OTOP2: Otopetrin 2

471/590

Serine

Isoleucine

chr9

CD300A: Cluster of Differentiation 300A

32/330

Serine

Leucine

chr11

MLLT3: Mixed-Lineage Leukemia Translocated To Chromosome 3 Protein

250/568

Methionine

Threonine

chr14

GATAD1: GATA Zinc Finger Domain Containing 1

158/325

Methionine

Valine

chr14

PEX1: Peroxisomal Biogenesis Factor 1

616/1416

Isoleucine

Valine

chr32

SYNPO2: Synaptopodin 2

1099/1267

Proline

Leucine

Bull Terrier (n = 5)

chr1

SELENOV: Selenoprotein V

580/627

Valine

Methionine

chr1

SIPA1L3: Signal Induced Proliferation Associated 1 Like 3

1409/1803

Threonine

Methionine

chr9

CACNG5: Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5

189/275

Threonine

Serine

chr9

TP53I13: Tumor Protein P53 Inducible Protein 13

91/394

Arginine

Glutamine

chr20

ADAMTS10: A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10

394/1103

Isoleucine

Threonine

chr22

PIBF1: Progesterone Immunomodulatory Binding Factor 1

719/723

Lysine

Stop

chr25

RP1L1: Retinitis Pigmentosa 1-Like 1 Protein

425/1956

Leucine

Methionine

Bullmastiff (n = 5)

chr3

LOC100855743: Uncharacterized gene

107/330

Aspartic acid

Glycine

chr4

LOC111093318: Uncharacterized gene

68/166

Arginine

Histidine

chr9

WDR81: WD Repeat Domain 81

185/1949

Alanine

Threonine

chr9

OR3A1H: Olfactory receptor family 3 subfamily A member 1H

232/315

Arginine

Cysteine

chr9

CACFD1: Calcium Channel Flower Domain Containing 1

165/172

Threonine

Methionine

chr17

LOXL3: Lysyl oxidase like 3

267/804

Leucine

Phenylalanine

Chow Chow (n = 4)

chr2

C2H16orf78: Chromosome 2 homolog 16 open reading frame 78

249/264

Glutamic acid

Aspartic acid

chr6

ZKSCAN5: Zinc Finger With KRAB And SCAN Domains 5

291/835

Valine

Isoleucine

chr6

UBN1: Ubinuclein 1

872/1169

Serine

Leucine

chr6

SLX4: SLX4 Structure-Specific Endonuclease Subunit

95/1733

Glutamic acid

Lysine

chr6

IFT140: Intraflagellar Transport 140

622/1459

Arginine

Tryptophan

chr6

CAPN15: Calpain 15

387/1153

Proline

Leucine

chr8

LTBP2: Latent Transforming Growth Factor Beta Binding Protein 2

674/1817

Threonine

Alanine

chr12

CEP162: Centrosomal Protein 162

419/1426

Arginine

Glutamine

chr20

NBEAL2: Neurobeachin-Like Protein 2

2236/2745

Glycine

Aspartic acid

chr21

LOC119864893: Uncharacterized gene

275/319

Glutamic acid

Aspartic acid

chr21

OR56A9: olfactory receptor family 56 subfamily A member 9

152/315

Asparagine

Serine

chr26

MPHOSPH9: M-Phase Phosphoprotein 9

891/1182

Threonine

Isoleucine

chr32

C32H4orf54: Chromosome 32 homolog 4 open reading frame 54

260/1803

Glycine

Arginine

Collie (n = 6)

chr8

CLEC14A: C-Type Lectin Domain Containing 14A

241/489

Glycine

Alanine

chr18

LOC102157137: Uncharacterized gene

152/310

Tryptophan

Arginine

Dalmatian (n = 5)

chr3

SLC2A9: Solute Carrier Family 2 Member 9

188/535

Cysteine

Phenylalanine

chr10

ANKRD53: Ankyrin Repeat Domain 53

326/507

Serine

Glycine

Doberman Pinscher (n = 4)

chr2

PLA2G5: Phospholipase A2 Group V

164/190

Arginine

Tryptophan

chr5

ACSF3: Acyl-CoA Synthetase Family Member 3

473/600

Arginine

Tryptophan

chr16

STAR: Steroidogenic acute regulatory protein

67/285

Leucine

Phenylalanine

Field Spaniel (n = 4)

chr1

LOC484505: Uncharacterized gene

199/2995

Alanine

Valine

Flat-coated Retriever (n = 7)

chr2

LACTBL1: Lactamase Beta Like 1

193/590

Methionine

Isoleucine

Irish Wolfhound (n = 4)

chr9

SDK2: Sidekick Cell Adhesion Molecule 2

83/2172

Arginine

Cysteine

chr14

CRHR2: Corticotropin Releasing Hormone Receptor 2

41/435

Valine

Methionine

chrX

LOC480918:Uncharacterized gene

77/247

Alanine

Proline

Keeshond (n = 5)

chr18

BLVRA: Biliverdin Reductase A

301/353

Valine

Isoleucine

chr18

PUS7: Pseudouridine Synthase 7

166/659

Phenylalanine

Leucine

Leonberger (n = 5)

chr9

GBGT1: Globoside Alpha-1,3-N-Acetylgalactosaminyltransferase 1

303/347

Arginine

Histidine

Manchester Terrier (n = 5)

chr6

MYH16: Myosin Heavy Chain 16

329/1993

Glycine

Arginine

chr6

GPR139: G Protein-Coupled Receptor 139

290/352

Arginine

Lysine

chr12

RAB44: Member RAS Oncogene Family 44

100/970

Glutamic acid

Lysine

chr20

DAPK3: Death Associated Protein Kinase 3

383/454

Glutamine

Glutamic acid

chr21

SERPINH1: Serpin Family H Member 1

14/418

Alanine

Threonine

Miniature Schnauzer (n = 5)

chr7

PDC: Phosducin

82/245

Arginine

Glycine

chr7

MAEL: Maelstrom Spermatogenic Transposon Silencer

85/438

Proline

Alanine

chr12

GPR63: G Protein-Coupled Receptor 63

324/419

Isoleucine

Threonine

chr35

LOC488316: Uncharacterized gene

40/487

Arginine

Cysteine

chr35

95/487

Glutamine

Stop

Newfoundland (n = 4)

chr5

ATP2C2: ATPase Secretory Pathway Ca2 + Transporting 2

179/945

Histidine

Leucine

Norwich Terrier (n = 4)

chr5

SLC12A4: Solute Carrier Family 12 Member 4

651/1094

Leucine

Valine

chr5

CTRL: Chymotrypsin-like protease

227/268

Glycine

Arginine

chr5

PLEKHG4: Pleckstrin Homology And RhoGEF Domain Containing G4

672/1195

Threonine

Serine

chr18

TPCN2: Two pore segment channel 2

175/926

Valine

Methionine

chr18

SNX32: Sorting Nexin 32

323/417

Arginine

Tryptophan

chr18

PCNX3: Pecanex homolog 3

576/2042

Arginine

Tryptophan

chr31

ZBTB21: Zinc Finger and BTB Domain Containing 21

300/1057

Glycine

Arginine

Rhodesian Ridgeback (n = 3)

chr3

SEL1L3: SEL1L family member 3

452/1156

Proline

Leucine

chr17

TOGARAM2: TOG Array Regulator Of Axonemal Microtubules 2

968/1146

Arginine

Serine

Samoyed (n = 5)

chr9

LGALS9: Galectin 9

190/355

Alanine

Proline

chr9

ERAL1: Era Like 12S Mitochondrial RRNA Chaperone 1

406/437

Arginine

Histidine

chr20

SH2D3A: SH2 Domain Containing 3A

531/602

Glycine

Serine

chr38

SLAMF8: SLAM Family Member 8

5/289

Tryptophan

Stop

Scottish Terrier (n = 3)

chr2

SREK1: Splicing Regulatory Glutamine/lysine-rich Protein 1

458/647

Arginine

Serine

chr17

SH2D6: SH2 Domain Containing 6

179/357

Threonine

Proline

St. Bernard (n = 6)

chr30

PRTG: Protogenin

553/1200

Arginine

Cysteine

Staffordshire Bull Terrier (n = 5)

chr35

H2AC8: H2A Clustered Histone 8

133/133

Tyrosine

Serine

Sussex Spaniel (n = 5)

chr2

CYLD: Lysine 63 Deubiquitinase

277/956

Aspartic acid

Asparagine

chr3

SEL1L3: SEL1L Family Member 3

8/1156

Histidine

Proline

chr5

COG4: Component Of Oligomeric Golgi Complex 4

682/788

Methionine

Leucine

chr6

EIF3B: Eukaryotic Translation Initiation Factor 3 Subunit B

735/785

Alanine

Threonine

chr6

GDPD3: Glycerophosphodiester Phosphodiesterase Domain Containing 3

184/320

Serine

Isoleucine

chr7

NENF: Neudesin Neurotrophic Factor

108/174

Aspartic acid

Glutamic acid

chr9

PRRC2B: Proline Rich Coiled-Coil 2B

102/2228

Threonine

Methionine

chr9

LCN2: Lipocalin 2

202/207

Arginine

Cysteine

chr11

LOC119873934: Uncharacterized gene

134/142

Leucine

Stop

chr11

RUSC2: RUN And SH3 Domain Containing 2

1197/1512

Glutamine

Arginine

chr11

OR13E1: Olfactory Receptor Family 13 Subfamily E Member 1

120/326

Arginine

Histidine

chr12

COL11A2: Collagen Type XI Alpha 2 Chain

93/1778

Arginine

Proline

chr15

OTOGL: Otogelin Like protein

1194/2343

Histidine

Glutamine

chr27

LMBR1L: Limb Development Membrane Protein 1 Like protein

229/489

Valine

Alanine

chr30

CEP152: Centrosomal Protein 152

849/1718

Valine

Isoleucine

chrX

HDAC6: Histone Deacetylase 6

130/1217

Glutamine

Arginine

chrX

CXHXorf66: chromosome X CXorf66 homolog

259/376

Arginine

Cysteine

Tibetan Terrier (n = 4)

chr27

LOC119866324: Uncharacterized gene

191/293

Serine

Asparagine

chr27

NANOGNB: NANOG Neighbor Homeobox

208/328

Proline

Leucine

Welsh Terrier (n = 4)

chr11

BNC2: Basonuclin 2

321/1136

Proline

Leucine

chr27

ABCD2: ATP Binding Cassette Subfamily D Member 2

631/742

Tyrosine

Cysteine