Table 2 GO enrichment analysis of ferroptosis-related differentially expressed genes (DEGs)

GO-BP

 GO:0006979

response to oxidative stress

53

1.66E-32

 GO:0031667

response to nutrient levels

54

2.78E-31

 GO:0071496

cellular response to external stimulus

43

9.36E-28

 GO:0034599

cellular response to oxidative stress

41

1.16E-27

 GO:0031669

cellular response to nutrient levels

37

3.05E-27

 GO:2001233

regulation of apoptotic signaling pathway

41

1.25E-22

 GO:0010038

response to metal ion

38

1.58E-21

 GO:0006914

autophagy

41

2.19E-19

 GO:0061919

process utilizing autophagic mechanism

41

2.19E-19

 GO:0035690

cellular response to drug

35

1.54E-18

GO-CC

 GO:0000407

phagophore assembly site

10

1.21E-11

 GO:0005925

focal adhesion

27

2.16E-11

 GO:0005924

cell-substrate adherens junction

27

2.55E-11

 GO:0030055

cell-substrate junction

27

3.19E-11

 GO:0042470

melanosome

14

2.67E-10

 GO:0048770

pigment granule

14

2.67E-10

 GO:0005776

autophagosome

12

6.78E-09

 GO:1902911

protein kinase complex

12

4.18E-08

 GO:0034045

phagophore assembly site membrane

6

5.07E-08

 GO:0031968

organelle outer membrane

15

1.64E-07

GO-MF

 GO:0031625

ubiquitin protein ligase binding

31

2.27E-17

 GO:0004674

protein serine/threonine kinase activity

24

1.03E-07

 GO:0050662

coenzyme binding

19

1.56E-07

 GO:0003697

single-stranded DNA binding

10

1.06E-05

 GO:0032182

ubiquitin-like protein binding

9

1.85E-05

 GO:0008198

ferrous iron binding

5

2.92E-05

 GO:0051219

phosphoprotein binding

8

4.42E-05

 GO:0003996

acyl-CoA ligase activity

4

8.96E-05

 GO:0016874

ligase activity

10

9.11E-05

 GO:0015175

neutral amino acid transmembrane transporter activity

5

0.000107