Fig. 2

Data pre-processing and differential expression analysis. (A) PCA results before correction of gene expression profiles in MI data. (B) PCA results after correction of gene expression profiles in MI data. (C) PCA results before correction of gene expression profiles in IS data. (D) PCA results after correction of gene expression profiles in IS data. (E) MI expression profile data case vs. control differential expression volcano plot, horizontal coordinate is log2FoldChange, vertical coordinate is -log10 (p.adjust). Red nodes indicate upregulated DEGs, blue nodes indicate downregulated DEGs, and grey nodes indicate genes that are not significantly differentially expressed. (F) IS expression profile data case vs. control differential expression volcano plot, horizontal coordinate is log2FoldChange, vertical coordinate is -log10 (p.adjust), red nodes indicate upregulated DEGs, blue nodes indicate downregulated DEGs, and grey nodes indicate genes that are not significantly differentially expressed