Table 1 Simulated power with a binary trait and n = 50,000 observations with an underlying disease prevalence of 0.2
From: Comparison of multiple imputation and other methods for the analysis of imputed genotypes
Odds ratios | Method | MAF ≥ 0.1 Rsq ≥ 0.8 | 0.01 ≥ MAF < 0.1 Rsq ≥ 0.8 | 0.01 ≤ MAF < 0.1 0.6 ≤ Rsq < 0.8 | 0.001 ≤ MAF < 0.01 0.3 ≤ Rsq < 0.6 | 0.001 ≤ MAF < 0.01 0.6 ≤ Rsq < 0.8 | 0.001 ≤ MAF < 0.01 Rsq ≥ 0.8 |
|---|---|---|---|---|---|---|---|
1–1.2 | MI SMCFCS | 0.42 | 0.05 | 0 | 0 | 0 | 0 |
Dosage | 0.42 | 0.05 | 0 | 0 | 0 | 0 | |
MRM | 0.43 | 0.05 | 0 | 0 | 0 | 0 | |
U-MIa | 0.42 | 0.04 | 0 | 0 | 0 | 0 | |
1.2–1.4 | MI SMCFCS | 1 | 0.6 | 0.2 | 0 | 0 | 0 |
Dosage | 1 | 0.6 | 0.2 | 0 | 0 | 0 | |
MRM | 1 | 0.61 | 0.23 | 0 | 0 | 0 | |
U-MIa | 1 | 0.57 | 0.07 | 0 | 0 | 0 | |
1.4–1.6 | MI SMCFCS | 1 | 0.94 | 0.68 | 0.01 | 0.02 | 0.09 |
Dosage | 1 | 0.94 | 0.66 | 0.01 | 0.02 | 0.08 | |
MRM | 1 | 0.95 | 0.71 | 0.02 | 0.03 | 0.10 | |
U-MIa | 1 | 0.91 | 0.44 | 0 | 0 | 0.05 | |
1.6–1.8 | MI SMCFCS | 1 | 1 | 0.98 | 0.03 | 0.14 | 0.32 |
Dosage | 1 | 1 | 0.98 | 0.04 | 0.14 | 0.31 | |
MRM | 1 | 1 | 0.98 | 0.06 | 0.16 | 0.34 | |
U-MIa | 1 | 0.99 | 0.80 | 0 | 0.03 | 0.22 | |
1.8–2.0 | MI SMCFCS | 1 | 1 | 1 | 0.13 | 0.27 | 0.53 |
Dosage | 1 | 1 | 1 | 0.18 | 0.26 | 0.51 | |
MRM | 1 | 1 | 1 | 0.19 | 0.29 | 0.54 | |
U-MIa | 1 | 1 | 0.92 | 0.03 | 0.10 | 0.42 | |
2.0 – 3.0 | MI SMCFCS | 1 | 1 | 1 | 0.63 | 0.81 | 0.91 |
Dosage | 1 | 1 | 1 | 0.66 | 0.80 | 0.90 | |
MRM | 1 | 1 | 1 | 0.66 | 0.80 | 0.91 | |
U-MIa | 1 | 1 | 1 | 0.29 | 0.61 | 0.85 |