Table 1 The presence of genetic basis of antimicrobial resistance-associated genes in the E. faecium AOG174 genome
Antibiotic class | Genetic mechanism | Resistance mechanism | Genetic localization |
|---|---|---|---|
Beta-lactam | Pbp5 mutation | Target modification | Intrinsic |
Aminoglycoside | aac(6’) | Drug modification | Acquired |
Fluoroquinolone | parC and gyrA mutation efm | Target modification Efflux pump | Intrinsic Acquired |
Tetracycline | Tet (O) gene | Target protection | Acquired |
Glycopeptide | vanHAX gene | Target modification | Acquired |
Macrolide | erm gene efm gene msr(C) gene | Target modification Efflux pump Efflux pump | Acquired Acquired Acquired |