Fig. 3
Clustered HMRs show distinct enhancer-associated characteristics compared to unclustered HMRs. A Venn diagram showing partially overlapping sets between three region datasets: All B cell HMRs (blue circle); clustered B cell HMRs (green circle; subset of All); and GM12878 super-enhancers (red circle) [26]. GM12878 is a tier 1 ENCODE lymphoblastoid cell line derived from EBV immortalized B cells. B Bar graph of HMR overlap with selected ChromHMM annotations: strong enhancer, weak enhancer, heterochromatin, repressed, insulator, weak transcription. The height of the bars represents the fraction of clustered and unclustered HMRs that overlap each annotation. Z-test of proportion p-values are shown, comparing HMR group proportion values for each ChromHMM annotation. C TF motif enrichment in clustered (left; green) and unclustered (right; blue) HMRs. Results are plotted as -log10p-value by fold enrichment, measured as percentage of target regions containing motif divided by the percentage of background regions. Background represents all clustered and unclustered HMRs