Fig. 2

(A) The circular-barplot showing the basic information of GEO datasets (GEO accession, source name and experiment type). A total of 83 datasets were included in the study of which 54 were gene expression microarray datasets from tissue, peripheral blood and fibroblast, 4 were gene expression RNA-Seq datasets from tissue, platelet and CD4 + Treg cell, and 25 were miRNA expression datasets including 1 RNA-Seq datasets from tissue and 24 microarray datasets from tissue, peripheral blood, serum and serum exosome. Nineteen DEMs and 309 DEGs were screened in CRCs versus normal controls (NCs). B Nineteen microRNAs (miRNAs) to 309 mRNAs network visualized by Cytoscape. There were 250 miRNA (up) – mRNA (down) pairs and 343 miRNA (down) – mRNA (up) pairs screened out by miRtarbase and Tarbase which contain experimentally validated miRNA-mRNA regulatory pairs. Orange dot represents the upregulated miRNAs/mRNAs in CRCs versus NCs, while purple dot represents the downregulated miRNAs/mRNAs in CRCs versus NCs