Fig. 5
From: CanISO: a database of genomic and transcriptomic variations in domestic dog (Canis lupus familiaris)
Isoform-centric analysis results. (a) Increased count of alternative splicing events in tumor condition compared to normal. Three events (APR, APA, and CE) showed the largest increase in the order. (b) Functional analysis results for 243 major isoforms switched genes that matched with human cancer census genes. Among them, 105 genes were enriched in a category related to cancer copy number alteration. (c) Venn diagram showing the selection procedure of tumor-specific isoforms. By excluding the overlapped normal isoforms and matching them to human cancer census genes, a total of 326 tumor isoforms (level 3) were selected as “CMT-specific isoforms