Fig. 3
From: The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates
ATF4 presence in mtDNA across diverse taxa. A The DNA recognition motif for human ATF4 transcription factor used for a comparison across diverse taxa. B Locations of human ATF4 transcription factor recognition sites identified using FIMO (black bars above mtDNA coding regions) within the mitochondrial genomes of diverse taxa: Gallus gallus, Homo sapiens, Alligator mississippiensis, Danio rerio and Drosophila melanogaster. Coding regions within the heavy strand (mtDNA genes, above line) and light strand (mtDNA genes, below line) of the mitochondrial DNA are displayed for reference, with subunits of the same electron transport complexes shown in the same colour. tRNAs are shown in purple. C Sequence allignment of the 16S rRNA region associated with ATF4 binding (shown with star in B, outlined in dashes in C) as well as 20 bp upstream and downstream of the site