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Table 1 Consensus motifs identified within mtDMRs of the mtDNA of chickens exposed to circadian stress. All significance values for the Homologous known vertebrate motifs identified through a comparison with vertebrate motif databases are shown where applicable. Sea P values were generated using XSTREME (Motif Discovery and Enrichment Analysis: Version 5.4.1 released on Sat Aug 21 19:23:23 2021 -0700) and represent the significance in the similarity between the sequence extracts and the motif sequence. The E value describes the same statistic accounting for multiple testing based on the number of identified motifs. It represents an estimate of the number of motifs that would be found with equal enrichment in shuffled versions of the positive sequences

From: The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates

Rank

Concensus sequence

Width (bp)

Number of sites within mtDMRs

Sea P value

E value

Homologous motif

1

SGACTSTG

8

14

 < 0.001

 < 0.001

HNF4G, HNF4A

2

AYWAKAA

7

16

 < 0.001

 < 0.0001

NA

3

ATTATGAA

8

13

 < 0.001

 < 0.0001

NA

4

ACWACAGCC

9

11

 < 0.001

 < 0.001

NA

5

CACCATCCT

9

17

 < 0.001

 < 0.0001

ATF4 DBD, ZNF324