Fig. 1

Introduction of the DARIC framework. A Schematic of the Preferential Interaction Score (PIS) definition. B Snapshots of chromosomes 2 and 6 showing the high correlation between PIS and PC1 values. C Flowchart of the DARIC pipeline for identifying genomic regions with significantly differential compartment changes. D Emission probability of the four-state Hidden Markov Model (HMM) model trained from the differential PIS between H1ESC and K562 cells. Values in the heatmap represent the mean value of PIS differences for each state. Strongly increased/decreased states are denoted as “Strong ± ”. Weakly increased/decreased states are denoted as “Weak ± ”. E Genomic coverage of the four states as shown in D. F Exemplar genome snapshot showing the PIS comparison of H1ESC and K562 and the output of DARIC, including statistical significance track (-log10P-value) and the segmentation of genome into four states