Fig. 2

Integration of multi-modal genomics data demonstrates the functional association between gene regulation and differential compartments revealed by DARIC. A-C Gene expression (A), DNase-seq chromatin accessibility (B), and H3K27ac intensity. (C) comparison between H1ESC and K562 cells in the four states. ***, p < 1e-3, Mann–Whitney U test. TPM, Transcript Per Million. RPM, Reads Per Million mapped reads. D-E Illustration and comparison of the lamina B1 DamID signals (D) and TSA-seq signals. E between H1ESC and K562 cells in the PIS strongly changed regions. F Snapshots at the MYB and SOX2 gene loci showing the PIS comparison between H1ESC and K562 cells, as well as the concordant changes in DamID and TSA-seq signals