Fig. 3

Comparison between DARIC and existing methods. A Genomic coverage of the four types of domains in terms of compartment changes. ‘AB’ represents a 50 kb genomic bin in compartment A in H1ESC that switch to compartment B in K562 cells. B Venn diagram representing the overlap between the ‘Strong + ’ state revealed by DARIC and the ‘BA’ state in PC1-based switching analysis. The numbers in the plot represent the numbers of 50 kb bins. C Violin plot showing the PIS differences for the three types of domains defined in (B). D-F Violin plots showing the comparisons of TSA-seq signal changes (D), lamina B1 DamID signal changes (E), and gene expression fold changes (F) in the three types of domains defined in (B). Gray distributions in each figure represent the signal changes for background regions that are randomly selected from the genome.***, p < 1e-3;n.s, not significant (p > 0.05), Mann-Whitney U test. G Venn diagram showing the overlap of genomic bins identified with increased PIS/PC1 values in K562 by DARIC and dcHiC. Numbers of 50 kb bins were shown in the diagram. H Enrichment of K562-specific genes for the three types of genomic regions defined in (G). I An exemplary region showing DARIC and dcHiC output with increased PIS in K562 cells