Fig. 4

DARIC is robust to technical variations in Hi-C data, such as choices of restriction enzymes and sequencing depth. A Heatmap showing the high correlation between PIS tracks generated from Hi-C data of different restriction enzymes, including HindIII, MboI, and DpnII. The three datasets are from GM12878. B Histograms showing the distributions of PIS calculated from Hi-C datasets with the three restriction enzymes, before and after normalization by DARIC. C Heatmap showing the high correlation of PIS calculated from Hi-C datasets at different sequencing depths. D Histograms showing the similar distributions of PIS from Hi-C data at different sequencing depths