Fig. 5

Transcriptional regulators analysis for TO system. (A) EVTs-specific regulon activity analysis. Left, Rank for regulons based on regulon specificity score (RSS); Middle, EVT clusters are higjlighted in the t-SNE map (colors dots); Right, Binarized regulon activity score (RAS) for regulons in the t-SNE map (purple dots). (B) Binary activity matrix for cell types-specific regulons. Regulons were determined to be active (black) if they exceeded a manually adjusted AUC regulon-specific threshold, or inactive under this threshold (white). (C) Identified regulon modules based on regulon connection specificity index (CSI) matrix, along with representative transcription factors, corresponding binding motifs, and associated cell types. (D) Average module activity scores mapped on t-SNE. (E) KEGG terms for the enrichment of downstream targets of each module regulators