Fig. 7

Cell-cell interactions in dNKs-EVT-TO co-cultures. (A) Putative ligand and receptor-based intercellular communication between dNKs and EVT-TO cell types. Left, circus plot. Color lines indicate ligands broadcast by the cell population of the same color and connect to cell populations where cognate receptors are expressed. The line thickness is proportional to the number of ligands where cognate receptors are present in the recipient cell population. Loops indicate autocrine circuits. Map quantifies potential communication, but does not account for anatomic position or boundaries of cell populations. Right, Heatmap for counts of predicted pairs. (B) Overview of HLA molecules-representative ligand-receptor interactions. P-values < 0.05 indicated by circle size. The means of the average expression level of cell-cell pairs indicated by colors. (C) Overview of selected ligand-receptor interactions. Immuno., immune checkpoints. (D) Diagram of the main receptors and ligands expressed on dNKs subsets and EVTs clusters that are involved in cytokines, chemokines and immune checkpoints. (E) Same as D but for angiogenesis, growth factors and signaling