Fig. 2

Cuproptosis subtypes and their corresponding clinical and pathway characteristics in NB. (A) unsupervised clustering of TARGET-NB samples according to the mRNA expression levels of the 10 cuproptosis-related genes (CUGs) (k index = 2); (B) t-Distributed Stochastic Neighbor Embedding (t-SNE) of the expression profiles of CUGs mRNAs in the TARGET-NB dataset stratified the samples into 2 groups: C1 and C2; (C) silhouette plot of the 2 groups; (D) clustering representation of the molecular subgroups; (E) Kaplan–Meier test curves of the molecular patterns of individuals with NB; (F) heatmap showing the association between the subtypes as well as different clinicopathological attributes; and (G) GSVA enrichment analysis test of biological pathways between C1 and C2