Fig. 5

Distinct pathways and tumor immune microenvironment (TIME) characteristics of NB patients as per the cuproptosis score values. (A, B) GSEA displaying the significantly enriched pathways in the (A) low-score (B) high-score groups; (C) associations between the cuproptosis score, stromal scores, and immune scores; (D) thermogram depicting varying expression of various cytokines among the 2 cuproptosis score groups; (E, F) boxplots showing (E) the abundance of 23 infiltrating immune cell types and (F) differences in the immune scores among the two cuproptosis score groups; and (G) differences in the expression of 10 cuproptosis-linked genes between the two cuproptosis score groups. (p < 0.05 *; p < 0.01 **; p < 0.001 ***)