Fig. 6

Differential interactions among B cells and other cell types in different stages. A The connectivity map shows the strength of interactions between B cells and other cell types in colored shells. The numbers represent the frequency of communication. Different colored circles represent different cell types. B The B_cells-centric molecular interactions of peripheral immune cells in severe-stage COVID-19 patient. P-values are represented by the size of the circle, and the ruler is shown on the right side of the graph. The color represents the average expression level of these two genes in the two cell clusters, and the darker the color, the higher the expression. The size of the bubble represents the -log10 value of the P value, and the larger the bubble, the more significant it is