Table 4 Significantly enriched functional union pathways of genes targeted by known microRNAs with an abundancy of more than 100 RPM in one milk fraction and significantly affected by feed restriction, from Tarbase v8 and Diana mirPath v3 with a P-value threshold of 0.05. ^* p-value resulting of DIANA miRPath analysis showing the probability that the examined pathway is significantly enriched with gene targets of the selected miRNAs

Protein processing in endoplasmic reticulum

8E-11

115

16

Hippo signaling pathway

2E-07

91

16

Cell cycle

9E-07

83

16

p53 signaling pathway

1E-06

53

16

Fatty acid metabolism

2E-06

28

16

Lysine degradation

2E-06

30

15

Adherens junction

2E-05

52

16

TGF-beta signaling pathway

2E-05

54

16

Other types of O-glycan biosynthesis

3E-05

18

13

Glycosaminoglycan biosynthesis—chondroitin sulfate / dermatan sulfate

4E-05

13

10

N-Glycan biosynthesis

1E-04

32

14

Spliceosome

1E-04

86

16

Endocytosis

2E-04

120

17

Sphingolipid signaling pathway

2E-04

71

17

Thyroid hormone signaling pathway

2E-04

72

17

Inositol phosphate metabolism

3E-04

41

15

HIF-1 signaling pathway

3E-04

68

16

TNF signaling pathway

3E-04

69

17

FoxO signaling pathway

6E-04

85

17

Phosphatidylinositol signaling system

0.001

50

16

Fatty acid biosynthesis

0.002

6

10

Ubiquitin mediated proteolysis

0.002

85

17

MAPK signaling pathway

0.004

140

17

Proteasome

0.004

31

13

ErbB signaling pathway

0.005

53

16

Glycosaminoglycan biosynthesis—keratan sulfate

0.005

9

10

Oocyte meiosis

0.005

65

16

DNA replication

0.006

23

11

Signaling pathways regulating pluripotency of stem cells

0.007

80

16

Steroid biosynthesis

0.007

13

7

Focal adhesion

0.007

116

17

RNA transport

0.008

94

17

RNA degradation

0.011

50

16

Estrogen signaling pathway

0.011

56

16

Neurotrophin signaling pathway

0.014

69

17

B cell receptor signaling pathway

0.017

43

17

mTOR signaling pathway

0.018

38

16

Wnt signaling pathway

0.020

76

16

ECM-receptor interaction

0.021

40

15

mRNA surveillance pathway

0.023

55

16

Biosynthesis of unsaturated fatty acids

0.029

13

15