Fig. 1
From: Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
Box plots of ADAR1 (ADAR), ADAR2 (ADARb1) and ADAR3 (ADARb2) expression, in transcripts per million (TPM). Panels A, B and C depict expression differences between control vs. MCMV-infected mice samples. Only ADAR1 expression differed significantly between control and infected samples (padj < 0.001), but not that of ADAR2 or ADAR3 (padj > 0.05). Panels D, E and F show expression in control vs. ZIKV-infected samples (PRJNA487357). Similar to MCMV infections, only ADAR1 expression differed significantly between control and infected samples (padj < 0.001), but not that of ADAR2 or ADAR3 (padj > 0.05). Panels G, H and I show expression in control vs. ZIKV-infected samples (PRJNA358758). Expression of all three genes differed significantly between control and infected samples (padj < 0.001), albeit in different directions (ADAR1 was over-, while ADAR2 and ADAR3 were under-expressed, respectively). Panels J, K and L show expression in control vs. ZIKV-infected human induced pluripotent neuroprogenitor stem cells (hiNPCs) samples (PRJNA551246). Infections with Cambodian (FSS13025) and Brazilian ZIKV (PE243) strains are shown separately. ADAR1 expression differed significantly between control and infected samples for both strains, and was also higher in FSS13025-infected samples compared to PE243V-infected ones (padj < 0.001 in all these comparisons). ADAR2 and ADAR3 expression did not differ significantly between conditions (padj > 0.05)