Fig. 2
From: Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections
ADAR editing differences between control and infected samples, shown as the box plots of the number of editing sites and the Alu/SINE Editing Index (AEI). Panels A and B show the editing sites and AEI, respectively, between control vs. MCMV-infected mice samples. Both differed significantly between control vs. MCMV-infected mice (p = 0.01129 and p = 0.0004, respectively). Panels C and D show the editing sites and AEI, respectively, between control vs. ZIKV-infected samples (PRJNA487357). Both the number of editing sites and the average editing rates differed significantly between control vs. ZIKV-infected samples (p = 0.01877 and p = 0.004, respectively). Panels E and F show the editing sites and AEI, respectively, between control vs. ZIKV-infected samples (PRJNA358758). Both the number of editing sites and AEI differed significantly between control vs. ZIKV-infected samples (p = 0.0007123 and p = 0.006, respectively). Panels G and H show the editing sites and AEI, respectively, between ZIKV-infected human induced pluripotent neuroprogenitor stem cells (hiNPCs) samples (PRJNA551246). Infections with Cambodian (FSS13025) and Brazilian ZIKV (PE243) strains are shown separately. Unlike other ZIKV-infection examples, no significant differences were detected in the number of editing sites, but both ZIKV strains had significantly higher AEI than controls (p < 0.0001), with no significant difference between strains